Aims & Scope
Journal of Ulcers (JU) publishes mechanistic research on the molecular and cellular pathophysiology of ulcerative diseases, focusing on disease pathways, biomarker discovery, and molecular mechanisms underlying ulcer formation and progression.
Ulcer Pathogenesis
Molecular Mechanisms
Cellular Pathways
Biomarker Discovery
Disease Models
Core Research Domains
Molecular Pathogenesis
- Cellular signaling pathways in ulcer formation
- Molecular mechanisms of mucosal barrier dysfunction
- Gene expression profiling in ulcerative diseases
- Protein-protein interactions in tissue damage
- Epigenetic modifications in chronic ulceration
- Oxidative stress and inflammatory mediators
Typical Fit:
"Identification of novel signaling cascades mediating Helicobacter pylori-induced gastric epithelial cell apoptosis through transcriptomic analysis"
Disease Biomarkers
- Discovery and validation of molecular biomarkers
- Proteomic signatures of ulcer progression
- Metabolomic profiling in ulcerative conditions
- Circulating biomarkers for disease monitoring
- Tissue-specific biomarker identification
- Multi-omics integration for biomarker panels
Typical Fit:
"Serum metabolomic fingerprinting reveals distinct biosignatures differentiating venous from arterial ulcer pathophysiology"
Cellular Mechanisms
- Epithelial cell dysfunction and death pathways
- Endothelial cell biology in vascular ulcers
- Immune cell infiltration and activation
- Fibroblast behavior in chronic wounds
- Stem cell dysfunction in impaired healing
- Cell-matrix interactions in tissue damage
Typical Fit:
"Characterization of autophagy dysregulation in diabetic foot ulcer keratinocytes using in vitro hyperglycemic models"
Disease Models
- Development of in vitro ulcer models
- Animal models of ulcerative diseases
- Three-dimensional tissue culture systems
- Organoid models for mechanistic studies
- Computational modeling of disease progression
- Model validation and translational relevance
Typical Fit:
"Establishment of a murine pressure ulcer model recapitulating human ischemia-reperfusion injury molecular signatures"
Secondary Focus Areas
Microbial Pathophysiology
- Host-pathogen molecular interactions (H. pylori, other bacteria)
- Microbiome composition and dysbiosis mechanisms
- Bacterial virulence factors and cellular targets
- Immune evasion strategies at molecular level
- Biofilm formation and persistence mechanisms
Vascular Pathophysiology
- Molecular basis of microvascular dysfunction
- Endothelial cell signaling in ischemia
- Angiogenesis pathway dysregulation
- Hemodynamic stress and cellular responses
- Vascular permeability molecular mechanisms
Metabolic Dysregulation
- Hyperglycemia-induced cellular dysfunction
- Metabolic pathway alterations in diabetic ulcers
- Mitochondrial dysfunction mechanisms
- Lipid metabolism and membrane integrity
- Energy metabolism in impaired tissue
Methodological Innovations
- Novel molecular profiling techniques
- Advanced imaging for cellular mechanisms
- High-throughput screening platforms
- Single-cell analysis methodologies
- Systems biology approaches
Emerging Research Frontiers
Article Types & Editorial Priorities
Priority 1: Fast-Track Review
- Original Research Articles
- Systematic Reviews & Meta-Analyses
- Methods & Protocols
- Validation Studies
Priority 2: Standard Review
- Short Communications
- Data Notes
- Technical Notes
- Perspectives
Rarely Considered
- Opinion Pieces (by invitation)
- Commentaries (by invitation)
- Case Reports (mechanistic only)
Editorial Standards & Requirements
Reporting Guidelines
- ARRIVE guidelines for animal studies
- MIQE guidelines for qPCR experiments
- PRISMA for systematic reviews
- STROBE for observational studies (if mechanistic)
- Appropriate statistical reporting standards
Data & Reproducibility
- Raw data deposition in public repositories
- Detailed methodology for reproducibility
- Statistical analysis code availability
- Biological replicates clearly stated
- Negative results encouraged if rigorous
Ethics & Compliance
- Institutional review board approval (human samples)
- Animal ethics committee approval (animal studies)
- Informed consent documentation
- Conflict of interest disclosure
- Funding source transparency
Publication Policies
- Preprints permitted and encouraged
- Open data strongly recommended
- Post-publication peer review enabled
- Corrections and retractions transparent
- ORCID identifiers required
Editorial Decision Metrics
21 days
First Decision
35%
Acceptance Rate
45 days
To Publication
Transparent
APC Structure
