Aims & Scope
Journal of Endocrinology and Hormones (JEH) publishes mechanistic research elucidating the molecular and cellular pathways underlying endocrine disorders and hormonal dysregulation. We focus on pathophysiological mechanisms, biomarker discovery, and disease models-not clinical management or therapeutic protocols.
Core Research Domains
Hormone Signaling Mechanisms Tier 1
- Receptor-ligand interactions and downstream signaling cascades
- Post-translational modifications in hormone signaling
- Cross-talk between endocrine and metabolic pathways
- Molecular mechanisms of hormone resistance
- Epigenetic regulation of hormone receptor expression
- Cellular models of hormone action and feedback loops
Metabolic Endocrine Pathophysiology Tier 1
- Molecular pathogenesis of diabetes mellitus (Type 1 and Type 2)
- Beta-cell dysfunction mechanisms and biomarkers
- Insulin resistance at molecular and cellular levels
- Glucagon signaling dysregulation in metabolic disease
- Adipokine signaling in metabolic syndrome pathogenesis
- Molecular mechanisms linking obesity to endocrine dysfunction
Thyroid & Adrenal Pathophysiology Tier 1
- Molecular mechanisms of thyroid hormone synthesis and secretion
- Autoimmune thyroid disease pathogenesis (Graves', Hashimoto's)
- Thyroid hormone transporter dysfunction
- HPA axis dysregulation mechanisms
- Adrenal steroidogenesis pathway alterations
- Molecular biomarkers for thyroid and adrenal disorders
Reproductive Endocrine Mechanisms Tier 1
- Gonadal hormone synthesis and regulation pathways
- Molecular pathogenesis of polycystic ovary syndrome (PCOS)
- Hypothalamic-pituitary-gonadal axis dysfunction
- Steroid hormone receptor signaling in reproductive tissues
- Molecular mechanisms of ovarian and testicular dysfunction
- Biomarkers for reproductive endocrine disorders
Secondary Focus Areas
Neuroendocrine Pathophysiology
Molecular mechanisms of hypothalamic-pituitary axis dysfunction, pituitary adenoma pathogenesis, growth hormone signaling defects, prolactin pathway dysregulation, and neuropeptide signaling in endocrine disease. Focus on mechanistic understanding, not clinical pituitary disorders management.
Endocrine Neoplasia Mechanisms
Molecular pathogenesis of hormone-producing tumors, oncogenic signaling in endocrine tissues, tumor suppressor mechanisms in endocrine glands, biomarkers for endocrine malignancies. Emphasis on cancer biology mechanisms, not oncological treatment protocols.
Bone & Mineral Metabolism
Molecular mechanisms of parathyroid hormone action, vitamin D signaling pathways, calcium homeostasis dysregulation, osteoblast-osteoclast signaling in metabolic bone disease. Focus on pathophysiology of osteoporosis and mineral disorders at molecular level.
Endocrine Toxicology & Disruptors
Molecular mechanisms of endocrine-disrupting chemicals (EDCs), receptor-mediated toxicity pathways, environmental hormone mimics and antagonists, cellular stress responses to endocrine toxins. Mechanistic toxicology, not environmental health policy.
Emerging Research Areas
AI-Driven Endocrine Research
Machine learning models for biomarker discovery, AI-based prediction of hormone signaling outcomes, computational modeling of endocrine pathways, deep learning for disease mechanism elucidation. Must include experimental validation of computational predictions.
Single-Cell Endocrine Biology
Single-cell transcriptomics and proteomics of endocrine tissues, cellular heterogeneity in hormone-producing organs, lineage tracing in endocrine development and disease, spatial transcriptomics of endocrine glands.
Organoid & 3D Culture Models
Endocrine organoid development and characterization, 3D culture systems for hormone signaling studies, patient-derived models for mechanistic research, microfluidic endocrine tissue models.
Circadian & Chronobiology
Molecular mechanisms of circadian hormone regulation, clock gene dysfunction in endocrine disease, temporal dynamics of hormone signaling pathways, chronopathophysiology of metabolic disorders.
Article Types & Priorities
Fast-Track Review (10-14 days to first decision)
Standard Review (21-28 days to first decision)
Requires Strong Mechanistic Justification
Editorial Standards & Requirements
Reporting Guidelines
- ARRIVE 2.0 for animal studies
- MIQE for qPCR experiments
- PRISMA for systematic reviews
- STROBE for observational studies (if mechanistic)
- CONSORT for interventional studies (if mechanistic)
Data Transparency
- Raw data deposition in public repositories required
- Omics data: GEO, ArrayExpress, or ProteomeXchange
- Structural data: PDB or EMDB
- Code availability for computational analyses
- Materials availability statements required
Ethics & Integrity
- IRB/IACUC approval required for human/animal studies
- Informed consent documentation
- Competing interests disclosure mandatory
- Funding source transparency
- COPE guidelines adherence
Preprint Policy
- Preprints welcomed (bioRxiv, medRxiv)
- No impact on novelty assessment
- Must disclose preprint DOI at submission
- Preprint servers must be non-commercial
- Version control required
